<i>Staphylococcus aureus</i> exhibits heterogeneous siderophore production within the vertebrate host.
basic_science · Level V
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- Record sourced from PubMed, PMID 31611408.
- Also identified by DOI 10.1073/pnas.1913991116 and PMC identifier 6825271.
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Abstract
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of <i>Staphylococcus aureus</i> siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.
Medical subject headings
- Siderophores
- Staphylococcus aureus