The influence of device handles in single-molecule experiments.
basic_science · Level V
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- Record sourced from PubMed, PMID 31621748.
- Also identified by DOI 10.1039/c9sm01376h.
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Abstract
We deduce a fully analytical model to predict the artifacts of the device handles in single molecule force spectroscopy experiments. As we show, neglecting the handle stiffness can lead to crucial overestimation or underestimation of the stability properties and unfolding thresholds of multistable molecules.