The Texture of Chromatin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31626764.
- Also identified by DOI 10.1016/j.cell.2019.09.026 and PMC identifier 7428196.
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Abstract
DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that the intrinsic physical properties of chromatin fibers dictate how torsional stress is partitioned to minimize these risks and facilitate DNA replication.
Medical subject headings
- Chromatin
- DNA Replication