PiRNAs Rise to Rescue Koalas.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31626765.
- Also identified by DOI 10.1016/j.cell.2019.09.025.
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Abstract
PIWI-interacting small RNAs (piRNAs) establish sequence-specific adaptive restriction of resident genomic parasites to guard genome integrity. In this issue of Cell, Yu, Koppetsch, et al. describe an innate piRNA-response that specifically fragments the viral RNA genome in the germline of recently invaded koalas. This first line of defense might ensure survival until adaptive immunity develops.
Medical subject headings
- Phascolarctidae