Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31630171.
- Also identified by DOI 10.1093/cid/ciz1000 and PMC identifier 7167332.
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Abstract
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.
Medical subject headings
- Streptococcus pyogenes
- beta-Lactam Resistance