Interval breast cancer is associated with other types of tumors.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 31641120.
- Also identified by DOI 10.1038/s41467-019-12652-1 and PMC identifier 6805891.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC of which 1,772 are interval and 13,074 screen-detected. Compared to women with screen-detected cancers, interval breast cancer patients are more likely to have a non-BC tumor before (Odds ratio (OR): 1.43 [1.19-1.70], P = 9.4 x 10<sup>-5</sup>) and after (OR: 1.28 [1.14-1.44], P = 4.70 x 10<sup>-5</sup>) breast cancer diagnosis, are more likely to report a family history of non-BC tumors and have a lower genetic risk score based on common variants for non-BC tumors. In conclusion, interval breast cancer is associated with other tumors and common cancer variants are unlikely to be responsible for this association. These findings could have implications for future screening and prevention programs.
Medical subject headings
- Breast Neoplasms
- Mass Screening
- Neoplasms