Unraveling the osteocyte in CKD-MBD post-renal transplantation.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31648693.
- Also identified by DOI 10.1016/j.kint.2019.07.021.
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Abstract
Changes in indices of mineral metabolism, bone protein expression, and bone turnover were assessed between pre- and post-renal transplant bone biopsies obtained 12 months apart. Circulating sclerostin and fibroblast growth factor 23 (FGF-23) levels decreased, and a low bone turnover state was highly prevalent on follow-up. In contrast, bone sclerostin expression increased, whereas FGF-23 bone expression was unchanged/decreased. These findings underscore the limitations of circulating biomarkers and the critical role of bone biopsy to understand osteocyte biology in chronic kidney disease-mineral bone disorder.
Medical subject headings
- Chronic Kidney Disease-Mineral and Bone Disorder
- Kidney Transplantation
- Renal Insufficiency, Chronic