Origami-paper-based device for microvesicle/exosome preconcentration and isolation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31650155.
- Also identified by DOI 10.1039/c9lc00796b.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
Medical subject headings
- Cell-Derived Microparticles
- Exosomes
- Paper