Intestinal microbiome composition and its relation to joint pain and inflammation.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31653850.
- Also identified by DOI 10.1038/s41467-019-12873-4 and PMC identifier 6814863.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.
Medical subject headings
- Arthralgia
- Gastrointestinal Microbiome
- Osteoarthritis, Knee