Biological process activity transformation of single cell gene expression for cross-species alignment.
Where this comes from
- Record sourced from PubMed, PMID 31653878.
- Also identified by DOI 10.1038/s41467-019-12924-w and PMC identifier 6814736.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.
Medical subject headings
- Computational Biology
- Gene Expression Profiling
- Sequence Analysis, RNA