The Immune-Mind Connection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31675492.
- Also identified by DOI 10.1016/j.cell.2019.10.012.
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Abstract
How does stress promote anxiety? In this issue of Cell, Fan et al. report that immune cells have a direct role in this process. They show that chronic stress promotes mitochondrial fission in CD4<sup>+</sup> T cells, causing increased synthesis of xanthine, which acts on the brain and induces anxiety-like behaviors.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Metabolic Diseases