The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31693880.
- Also identified by DOI 10.1016/j.cmet.2019.10.010.
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Abstract
Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key components of the xCT-glutamate→mGluR5-2-AG→CB1R-SREBP1-FASN paracrine communication system, Choi et al. identified potential new targets for drugs for ALD.
Medical subject headings
- Hepatic Stellate Cells
- Liver Diseases, Alcoholic