Chemotaxis as a navigation strategy to boost range expansion.

Abstract

Bacterial chemotaxis, the directed movement of cells along gradients of chemoattractants, is among the best-characterized subjects in molecular biology^1-10, but much less is known about its physiological roles¹¹. It is commonly seen as a starvation response when nutrients run out, or as an escape response from harmful situations^12-16. Here we identify an alternative role of chemotaxis by systematically examining the spatiotemporal dynamics of Escherichia coli in soft agar^12,17,18. Chemotaxis in nutrient-replete conditions promotes the expansion of bacterial populations into unoccupied territories well before nutrients run out in the current environment. Low levels of chemoattractants act as aroma-like cues in this process, establishing the direction and enhancing the speed of population movement along the self-generated attractant gradients. This process of navigated range expansion spreads faster and yields larger population gains than unguided expansion following the canonical Fisher-Kolmogorov dynamics^19,20 and is therefore a general strategy to promote population growth in spatially extended, nutrient-replete environments.