Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31699909.
- Also identified by DOI 10.1126/science.aaw9830.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chorev <i>et al</i> (Reports, 16 November 2018, p. 829) describe mass spectrometry on mitochondrial membrane proteins ionized directly from their native environment. However, the assignments made to measured masses are incorrect or inconclusive and lack experimental validation. The proteins are not in their "native" condition: They have been stripped of tightly bound lipids, and the complexes are fragmented or in physiologically irrelevant oligomeric states.
Medical subject headings
- Lipids
- Membrane Proteins