EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI.

Zheng, Shijie C; Breeze, Charles E; Beck, Stephan; Dong, Danyue; Zhu, Tianyu; Ma, Liangxiao; Ye, Wei; Zhang, Guoqing et al. · Bioinformatics · 2019

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Record sourced from PubMed, PMID 31710662.
Also identified by DOI 10.1093/bioinformatics/btz833 and PMC identifier 7703755.
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Abstract

It is well recognized that cell-type heterogeneity hampers the interpretation of Epigenome-Wide Association Studies (EWAS). Many tools have emerged to address this issue, including several R/Bioconductor packages that infer cell-type composition. Here we present a web application for cell-type deconvolution, which offers the functionality of our EpiDISH Bioconductor/R package in a user-friendly GUI environment. Users can upload their data to infer cell-type composition and differentially methylated cytosines in individual cell-types (DMCTs) for a range of different tissues. EpiDISH web server is implemented with Shiny in R, and is freely available at https://www.biosino.org/EpiDISH/.

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