Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31724046.
- Also identified by DOI 10.1093/cid/ciz823 and PMC identifier 6853757.
- Licence recorded as CC BY-NC-ND.
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Abstract
Cefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a "Trojan horse" active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.
Medical subject headings
- Anti-Bacterial Agents
- Cephalosporins
- Siderophores