Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31745081.
- Also identified by DOI 10.1038/s41467-019-13217-y and PMC identifier 6864097.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NP<sup>Calb</sup>), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of opto-tagged NP<sup>Calb</sup> neurons is augmented prior to the onset of eye movements during REM sleep. Optogenetic activation of NP<sup>Calb</sup> neurons triggers eye movements selectively during REM sleep, while their genetic ablation or optogenetic silencing suppresses them. None of these perturbations led to a change in the duration of REM sleep episodes. Our study provides the first evidence for a brainstem premotor command contributing to the control of eye movements selectively during REM sleep in the mammalian brain.
Medical subject headings
- Eye Movements
- Medulla Oblongata
- Motor Neurons
- Neurons