Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31747016.
- Also identified by DOI 10.1093/infdis/jiz552 and PMC identifier 7368165.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nipah virus (NiV; family Paramyxoviridae, genus Henipavirus) infection can cause severe respiratory and neurological disease in humans. The pathophysiology of disease is not fully understood, and it may vary by presentation and clinical course. In this study, we investigate changes in blood chemistry in NiV-infected Syrian hamsters that survived or succumbed to disease. Increased sodium and magnesium and decreased albumin and lactate levels were detected in animals euthanized with severe clinical disease compared with mock-infected controls. When subjects were grouped by clinical syndrome, additional trends were discernable, highlighting changes associated with either respiratory or neurological disease.
Medical subject headings
- Henipavirus Infections
- Magnesium
- Nipah Virus
- Serum Albumin
- Sodium