Current Approaches to Germline Cancer Genetic Testing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31756137.
- Also identified by DOI 10.1146/annurev-med-052318-101009.
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Abstract
The prevalence of genetic predisposition to cancer is greater than initially appreciated, yet most affected individuals remain undiagnosed. Deleterious germline variants in cancer predisposition genes are implicated in 1 in 10 cases of advanced cancer. Next-generation sequencing technologies have made germline and tumor DNA sequencing more accessible and less expensive. Expanded access to clinical genetic testing will improve identification of individuals with genetic predisposition to cancer and provide opportunities to effectively reduce morbidity through precision cancer therapies and surveillance. Cross-disciplinary clinical education in genomic medicine is needed to translate advances in genomic medicine into improved health outcomes.
Medical subject headings
- Breast Neoplasms
- Colorectal Neoplasms
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Ovarian Neoplasms