Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 31763684.
- Also identified by DOI 10.1002/bjs.11443 and PMC identifier 7453628.
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Abstract
A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed.
Medical subject headings
- Mutation
- Stomach Neoplasms
- Tumor Suppressor Protein p53