Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 31767439.
- Also identified by DOI 10.1016/j.ophtha.2019.10.026 and PMC identifier 7093221.
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Abstract
Whole genome sequencing was performed on 20 matched blood and aqueous samples; tumor-associated chromosomal changes were found in 0/20 blood vs. 11/20 aqueous samples along with shorter DNA fragments. Thus, aqueous is superior to blood as a liquid biopsy for retinoblastoma.
Medical subject headings
- Aqueous Humor
- Retinal Neoplasms
- Retinoblastoma
- Retinoblastoma Binding Proteins
- Ubiquitin-Protein Ligases