Therapeutic Potential of the miRNA-ATM Axis in the Management of Tumor Radioresistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31767626.
- Also identified by DOI 10.1158/0008-5472.CAN-19-1807.
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Abstract
The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.
Medical subject headings
- Antineoplastic Agents
- Ataxia Telangiectasia Mutated Proteins
- Chemoradiotherapy
- MicroRNAs
- Neoplasms
- Radiation Tolerance