Oxidation of difluorocarbene and subsequent trifluoromethoxylation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31767850.
- Also identified by DOI 10.1038/s41467-019-13359-z and PMC identifier 6877537.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, <sup>18</sup>O-trifluoromethoxylation, the observation of AgOCF<sub>3</sub> species, and DFT calculations.