Treatment and Prognosis of Radiation-Associated Breast Angiosarcoma in a Nationwide Population.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 31773514.
- Also identified by DOI 10.1245/s10434-019-08085-1 and PMC identifier 7060227.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Radiation-associated angiosarcoma of the breast (RAASB) is an aggressive malignancy that is increasing in incidence. Only a few previous population-based studies have reported the results of RAASB treatment. A search for RAASB patients was carried out in the Finnish Cancer Registry, and treatment data were collected to identify prognostic factors for survival. Overall, 50 RAASB patients were identified. The median follow-up time was 5.4 years (range 0.4-15.6), and the 5-year overall survival rate was 69%. Forty-seven (94%) patients were operated on with curative intent. Among these patients, the 5-year local recurrence-free survival, distant recurrence-free survival, and overall survival rates were 62%, 75%, and 74%, respectively. A larger planned surgical margin was associated with improved survival. We found that the majority of RAASB patients were eligible for radical surgical management in this population-based analysis. With radical surgery, the prognosis is relatively good.
Medical subject headings
- Breast Neoplasms
- Hemangiosarcoma
- Neoplasms, Radiation-Induced
- Radiotherapy