Fabrication of novel MXene (Ti₃C₂)/polyacrylamide nanocomposite hydrogels with enhanced mechanical and drug release properties.

Abstract

A highly stretchable nanocomposite (NC) hydrogel was fabricated via in situ free radical polymerization of acrylamide. In particular, an exfoliated two-dimensional MXene (Ti₃C₂) nanosheet was utilized as a crosslinker instead of traditional organic crosslinkers. The exfoliated Ti₃C₂ nanosheets were confirmed by atomic force microscopy (AFM) and dynamic light scattering (DLS) measurements. Compared with traditional organic crosslinked N,N-methylene bisacrylamide (BIS)/polyacrylamide (PAM) hydrogels (fracture strength of 32.0 kPa and elongation of 109.6%), the synthesized Ti₃C₂/PAM NC hydrogels exhibited greatly improved mechanical properties with fracture strengths of 66.5 to 102.7 kPa, compressive strengths of 400.6 to 819.4 kPa and elongations at break of 2158.6% to 3047.5% as the Ti₃C₂ content increases from 0.0145% to 0.0436%. The enhanced mechanical performances can be attributed to the honeycomb-like fine structure with uniform pores as well as more flexible polymer chains in NC hydrogel networks. When loaded with drugs, Ti₃C₂/PAM NC hydrogels exhibited good sustained-release performance, higher drug loading amounts (97.5-127.7 mg g^-1) and higher percentage releases (62.1-81.4%), greatly superior to those of the BIS/PAM hydrogel (46.4 mg g^-1, 45.0%). Our work reveals the application of MXene materials in the fabrication of NC hydrogels with enhanced mechanical and drug release behaviors.