Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity.

Jin, Liguo; Hu, Ping; Wang, Yinyin; Wu, Luojia; Qin, Kang; Cheng, Haoxin; Wang, Shuhua; Pan, Bingxing et al. · Adv Mater · 2020

basic_science · Level V

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Abstract

A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.

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