Saved by the Matrix: UPR Independent Survival under ER Stress.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31778650.
- Also identified by DOI 10.1016/j.cell.2019.11.012.
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Abstract
Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.
Medical subject headings
- Hyaluronoglucosaminidase
- Longevity