A once-a-month oral contraceptive.

Kirtane, Ameya R; Hua, Tiffany; Hayward, Alison; Bajpayee, Ambika; Wahane, Aniket; Lopes, Aaron; Bensel, Taylor; Ma, Lihong et al. · Sci Transl Med · 2019

basic_science · Level V

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Abstract

Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

Medical subject headings