¹⁸F-FDG PET/CT in Left-Ventricular Assist Device Infection: Initial Results Supporting the Usefulness of Image-Guided Therapy.

Abstract

Accurate definition of the extent and severity of left-ventricular assist device (LVAD) infection may facilitate therapeutic decision making and targeted surgical intervention. Here, we explore the value of ¹⁸F-FDG PET/CT for guidance of patient management. <b>Methods:</b> Fifty-seven LVAD-carrying patients received 85 whole-body ¹⁸F-FDG PET/CT scans for the work-up of device infection. Clinical follow-up was obtained for up to 2 y. <b>Results:</b> PET/CT showed various patterns of infectious involvement of the 4 LVAD components: driveline entry point (77% of patients), subcutaneous driveline path (87%), pump pocket (49%), and outflow tract (58%). Driveline smears revealed <i>Staphylococcus</i> or <i>Pseudomonas</i> strains as the underlying pathogen in most cases (48 and 34%, respectively). At receiver-operating-characteristic analysis, an ¹⁸F-FDG SUV of more than 2.5 was most accurate to identify smear-positive driveline infection. Infection of 3 or all 4 LVAD components showed a trend toward lower survival than did infection of 2 or fewer components (<i>P</i> = 0.089), whereas involvement of thoracic lymph nodes was significantly associated with an adverse outcome (<i>P</i> = 0.001 for nodal SUV above vs. below median). Finally, patients who underwent early surgical revision within 3 mo after PET/CT (<i>n</i> = 21) required significantly less inpatient hospital care during follow-up than did those receiving delayed surgical revision (<i>n</i> = 11; <i>P</i> < 0.05). <b>Conclusion:</b> Whole-body ¹⁸F-FDG PET/CT identifies the extent of LVAD infection and predicts adverse outcome. Initial experience suggests that early image-guided surgical intervention may facilitate a less complicated subsequent course.