Gene Editing Expands the Donor Pool for CCR5-Negative Stem Cell Transplants.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31809736.
- Also identified by DOI 10.1016/j.stem.2019.11.006.
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Abstract
Cell therapy efforts for treating HIV+ patients are challenged by limited availability of donors with naturally occurring CCR5 mutations conferring resistance. Xu et al. (2019) report a CRISPR-based method for disrupting CCR5 in hematopoietic stem cells prior to transplant, providing a proof of concept for expanding the pool of potential donors.
Medical subject headings
- HIV Infections
- Precursor Cell Lymphoblastic Leukemia-Lymphoma