Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31813823.
- Also identified by DOI 10.1016/j.cmet.2019.11.010.
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Abstract
Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment.
Medical subject headings
- Energy Metabolism
- Lipid Metabolism
- Neoplasms
- Neoplastic Stem Cells
- Signal Transduction
- Stress, Physiological