Fast and accurate long-read assembly with wtdbg2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31819265.
- Also identified by DOI 10.1038/s41592-019-0669-3 and PMC identifier 7004874.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Existing long-read assemblers require thousands of central processing unit hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2-17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future.
Medical subject headings
- High-Throughput Nucleotide Sequencing