Beyond depression: Other uses for tricyclic antidepressants.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31821138.
- Also identified by DOI 10.3949/ccjm.86a.19005.
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Abstract
Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.
Medical subject headings
- Antidepressive Agents, Tricyclic
- Drug Repositioning