A model of DNA damage response activation at stalled replication forks by SPRTN.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31831745.
- Also identified by DOI 10.1038/s41467-019-13610-7 and PMC identifier 6908633.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
Medical subject headings
- DNA Damage
- DNA Replication
- DNA-Binding Proteins