Benchmarking network algorithms for contextualizing genes of interest.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31860671.
- Also identified by DOI 10.1371/journal.pcbi.1007403 and PMC identifier 6944391.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Computational approaches have shown promise in contextualizing genes of interest with known molecular interactions. In this work, we evaluate seventeen previously published algorithms based on characteristics of their output and their performance in three tasks: cross validation, prediction of drug targets, and behavior with random input. Our work highlights strengths and weaknesses of each algorithm and results in a recommendation of algorithms best suited for performing different tasks.
Medical subject headings
- Algorithms
- Gene Regulatory Networks
- Models, Genetic