Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31862977.
- Also identified by DOI 10.1038/s41467-019-13812-z and PMC identifier 6925219.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood-brain barrier (BBB) integrity in this process remains unclear. Using simultaneous in vivo imaging, we demonstrated that systemic inflammation induces CCR5-dependent migration of brain resident microglia to the cerebral vasculature. Vessel-associated microglia initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 and make physical contact with endothelial cells. During sustained inflammation, microglia phagocytose astrocytic end-feet and impair BBB function. Our results show microglia play a dual role in maintaining BBB integrity with implications for elucidating how systemic immune-activation impacts neural functions.
Medical subject headings
- Blood-Brain Barrier
- Cerebrovascular Circulation
- Endothelial Cells
- Lupus Erythematosus, Systemic
- Microglia