Sirtuin 6 and renal injury: another link in the β-catenin chain?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31901350.
- Also identified by DOI 10.1016/j.kint.2019.09.022.
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Abstract
A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6's deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and β-catenin within the broader context of β-catenin signaling and injury.
Medical subject headings
- Kidney Diseases
- beta Catenin