Association of postoperative covert stroke and cognitive dysfunction among elderly patients undergoing non-cardiac surgery: protocol for a prospective cohort study (PRECISION study).
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31911527.
- Also identified by DOI 10.1136/bmjopen-2019-034657 and PMC identifier 6955561.
- Licence recorded as CC BY-NC.
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Abstract
The incidence of covert stroke and cognitive dysfunction has gradually increased due to an ageing population. Recently, a prospective cohort study reported perioperative covert stroke was associated with an increased risk of postoperative cognitive dysfunction (POCD) 1 year after non-cardiac surgery. However, the mechanism remains unclear. This is a prospective observational trial aiming to investigate the cumulative incidence of perioperative covert stroke and test the hypothesis that perioperative covert stroke associates with POCD in elderly patients undergoing non-cardiac and non-neurological surgery. Data on risk factors, brain MRI, cognitive function evaluation and serum immune-inflammatory cytokines will be collected and analysed. Ethical approval has been granted by the Medical Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-027-02). The results of this study will be disseminated through presentations at scientific conferences and publication in scientific journals. NCT03081429.
Medical subject headings
- Cognition
- Cognitive Dysfunction
- Postoperative Complications
- Stroke
- Surgical Procedures, Operative