Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31916575.
- Also identified by DOI 10.1093/cid/ciaa022.
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Abstract
Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.
Medical subject headings
- Fasciitis, Necrotizing
- Soft Tissue Infections
- Streptococcal Infections