Elite Intratumoral T-cell Clonotypes (The 1%) Effect "Trickle-Down Cytotoxicity".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31919138.
- Also identified by DOI 10.1158/1078-0432.CCR-19-3788.
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Abstract
Careful study of T-cell clonal dynamics in patients with non-small cell lung cancer treated with neoadjuvant nivolumab suggests that successful trafficking of clones from a proliferative burst in the periphery to the tumor associates with major pathologic response. Integration of these findings with functional analysis may augment current therapeutic strategies.<i>See related article by Zhang et al., p. 1327</i>.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms