Image-guided neural activity manipulation with a paramagnetic drug.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31919353.
- Also identified by DOI 10.1038/s41467-019-13933-5 and PMC identifier 6952355.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.
Medical subject headings
- Brain
- Brain Waves
- Magnetic Resonance Imaging
- Muscimol