Stereotactic body radiation therapy planning for liver tumors using functional images from dual-energy computed tomography.

Abstract

This study aimed to generate a functional image of the liver using dual-energy computed tomography (DECT) and a functional-image-based stereotactic body radiation therapy plan to minimize the dose to the volume of the functional liver (V_fl). A normalized iodine density (NID) map was generated for fifteen patients with liver tumors. The volume of liver with an NID < 0.46 was defined as V_fl, and the ratio between V_fl and the total volume of the liver (FLR) was calculated. The relationship between the FLR and Fibrosis-4 (FIB-4) was assessed. For patients with 15% < FLR < 85%, functional volumetric modulated-arc therapy plans (F-VMAT) were retrospectively generated to preserve V_fl, and compared to the clinical plans (C-VMAT). FLR showed a significantly strong correlation with FIB-4 (r = -0.71, p < 0.01). For ten generated F-VMAT plans, the dosimetric parameters of D_99%, D_50%, D_1% and the conformity index were comparable to those of the C-VMAT (p > 0.05). For V_fl, F-VMAT plans achieved lower V_5Gy (122.4 ± 31.7 vs 181.1 ± 57.3 cc), V_10Gy (44.4 ± 22.2 vs 98.2 ± 33.3 cc), V_15Gy (22.6 ± 20.3 vs 49.8 ± 33.7 cc), V_20Gy (11.6 ± 14.1 vs 24.9 ± 25.1 cc), and D_mean (3.9 ± 2.3 vs 5.8 ± 3.0 Gy) values than the C-VMAT plans (p < 0.01). The functional image derived from DECT was successfully used, allowing for a reduction in the dose to the V_fl without compromising target coverage.