Visualization of circular RNAs and their internal splicing events from transcriptomic data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31950978.
- Also identified by DOI 10.1093/bioinformatics/btaa033.
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Abstract
Circular RNAs (circRNAs) are proved to have unique compositions and splicing events distinct from canonical mRNAs. However, there is no visualization tool designed for the exploration of complex splicing patterns in circRNA transcriptomes. Here, we present CIRI-vis, a Java command-line tool for quantifying and visualizing circRNAs by integrating the alignments and junctions of circular transcripts. CIRI-vis can be applied to visualize the internal structure and isoform abundance of circRNAs and perform circRNA transcriptome comparison across multiple samples. https://sourceforge.net/projects/ciri/files/CIRI-vis. Supplementary data are available at Bioinformatics online.
Medical subject headings
- RNA, Circular
- Transcriptome