May the (Mechanical) Force Be with AT2.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31951518.
- Also identified by DOI 10.1016/j.cell.2019.12.020 and PMC identifier 7388678.
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Abstract
Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated fibrosis, initiating a new chapter in understanding what underlies the periphery to center progression of this lung disease.
Medical subject headings
- Alveolar Epithelial Cells
- Pulmonary Fibrosis