SnapShot: Splicing Alterations in Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31951519.
- Also identified by DOI 10.1016/j.cell.2019.12.011 and PMC identifier 7291876.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.
Medical subject headings
- Alternative Splicing
- Neoplasms
- RNA Splice Sites