Stabilizing HIF to Ameliorate Anemia.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31951520.
- Also identified by DOI 10.1016/j.cell.2019.12.010.
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Abstract
Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
Medical subject headings
- Anemia
- Glycine
- Hypoxia-Inducible Factor 1
- Isoquinolines