The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31951565.
- Also identified by DOI 10.1016/j.cmet.2019.12.007.
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Abstract
Although confirmed as the primary lipophilic antioxidant molecule endogenously produced by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently, both Bersuker et al. (2019) and Doll et al. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independent ferroptosis.
Medical subject headings
- Antioxidants
- Glutathione