The Integrated Stress Response: A Central Memory Switch in Down Syndrome.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 31951566.
- Also identified by DOI 10.1016/j.cmet.2019.12.008.
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Abstract
Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.
Medical subject headings
- Down Syndrome