Single Dose of Doxycycline for the Prevention of Tick-borne Relapsing Fever.

Binenbaum, Yoav; Ben-Ami, Ronen; Baneth, Gad; Langford, Boaz; Negev, Yoav; Friedlander, Edwa; Shasha, David; Tau, Luba et al. · Clin Infect Dis · 2020

case_series · Level IV

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Abstract

The current postexposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days' doxycycline. In this observational study of 77 spelunkers at high risk for TBRF, a single dose of 100 mg doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.

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