SYNPLA, a method to identify synapses displaying plasticity after learning.
basic_science · Level V
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- Record sourced from PubMed, PMID 31974314.
- Also identified by DOI 10.1073/pnas.1919911117 and PMC identifier 7022215.
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Abstract
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.
Medical subject headings
- High-Throughput Screening Assays
- Learning
- Neuronal Plasticity
- Protein Interaction Mapping
- Synapses